What game do you think has been played the most in history?

Not just the opening but a mainline with whatever small variations?

With out doubt Sicilian d6 variation into Najdorf. From there I would have thought the main line and the poisened pawn variation are equaly popular. You could just trawl databases to answer your question!

I'd say  Bobby Fischer's game of the century  Frank Marshals win over Amos Burn (Pipe Game) and Paul Morphys Opera Game.

Draughts gets played a lot.

petershaby and others,

                I've got alot of DIY responses from people on here and I am looking around the net for knowledge, but I am new to taking chess seriously and it's common forum behavior at first to ask any kind of question to meet people and see who you get along with.

               Nonetheless thanks for the database tip.