I know, 50 move rule!!
Can you draw this position?
Here's an example of FIDE ruling that white's clock in this situation would not be a draw. https://en.wikipedia.org/wiki/Monika_So%C4%87ko#Rules_appeal_in_2008
It seems like USCF policy is different, and is somewhat controversial. It requires a forced win. That means 2 kings and 2 knights is a draw if time runs out, unlike the FIDE ruling above. Still, the puzzle I made would be a win for black, but only because a win is forceable. https://en.wikipedia.org/wiki/Rules_of_chess#Timing
So I was wrong: white to play and lose, not draw. Except on live chess on the internets. End thread.
A thorough refutation, at least over the board. All of white's legal moves lose.
1.a4 Nc2#
1.Na4 Nc2#
1.Nb5 Nc2#
1.Nd5 Nc2#
1.Ne4 Nc2#
1.N3e2 Nc2#
1.Nd1 Nc2#
1.N1e2 Nc2# (1...Nb3#)
1.Nd3 Nc2# (1...Nb3#)
1.Nb3 Nc2# (1...Nxb3#)
So there must be some trickery going on off the board...
I would imagine USCF rules would be specific enough to state that mate must be impossible regardless of the play of both sides -- I'm not sure what else the definition would be. The given position doesn't meet that definition because mate is possible depending on how both sides play.
Whether a king and knight will be theoretically enough material to mate will depend on the position the other side has.