If you're not looking to play something interesting such as the Dutch, the Benoni or the KID, then the Slav is a good choice. (1.d4 d5, and if 2.c4, then 2...c6.) It's a principal move that doesn't lock in your bishop. Just mind the checks on a4/b5 if applicable.
You can try to spice things up by threatening to take on c4, like in the semi-Slav.
Also there is nothing wrong with the Queen's gambit or the Nimzo-Indian, but I consider these more difficult. You can look a little cramped with black and you need a counter punch in the centre at some point. If you're not ready for that then don't bother.
Hello i have a Question. What should my defenses against D4 be? The only defense i know is the dutch defense which i've only had the chance to play once. but what else should i try? My opponents don't play D4 very often but i would like a back up plan in case they do. Thanks for your answeres!