Wrong approach!
It's not about weak and strong. It's about style. If you research all of your opponents, you might have an opening to play against aggressive, impatient players and another for those that prefer safety and a slow and methodical approach.
In other words, you see who you are facing in say, the 4th round the US Open, and you do your homework, and you see that he's a very aggressive, tactical play that plays nothing but the Najdorf, Grunfeld, and very aggressive variations of e4 openings. You know you are going to get Black against him. 1...e5 or 1...c6 is probably your best bet.
Next, in round 5, where you know you are getting White against a very cautious player that plays the Sicilian Kan. Maybe throw the Morra Gambit against him, and if he goes c3-Sicilian on you, there are options for White to push.
It's not about weak and strong.
I have tried to ask this question once before, but without much success. Anyway I will try again.
In any sport you can only meet three types of players. A player that is better than you, a player that is equal, and a player that is weaker than you. This in turn tell me that I need only to play 6 openings. 3 for white and 3 for black.
What 3 openings do you think I should play against a weaker, an equal and a stronger player as black, and the same for white?