Throughout his life, Camus was deeply concerned with the problem of human suffering in an indifferent world. In The Plague, Camus addresses the collective response to catastrophe when a large city in Algeria is isolated due to an outbreak of the bubonic plague. Although the effort to alleviate and prevent human suffering seems to make little or no difference in the ravages of the plague, Camus asserts that perseverance in the face of tragedy is a noble struggle even if it ultimately fails to make an appreciable difference. Such catastrophes test the tension between individual self-interest and social responsibility.