The Sistine Chapel ceiling, painted by Michelangelo between 1508 and 1512, is a cornerstone work of High Renaissance art. It was painted at the commission of Pope Julius II. The ceiling's various painted elements form part of a larger scheme of decoration within the Chapel, which includes the large fresco The Last Judgment on the sanctuary wall, also by Michelangelo, wall paintings by several leading painters of the late 15th century including Sandro Botticelli, Domenico Ghirlandaio and Pietro Perugino, and a set of large tapestries by Raphael, the whole illustrating much of the doctrine of the Catholic Church. Central to the ceiling decoration are nine scenes from the Book of Genesis of which The Creation of Adam is the best known, having an iconic standing equalled only by Leonardo da Vinci's Mona Lisa, the hands of God and Adam being reproduced in countless imitations.