I would think the should be fairly easy. You can create a search filter that will give you all the games in a particular opening, though I don't know how well it handles transpositions. Then, do an AND filter on those results looking for the checkmates.
I don't have my computer un front of me so I don't know if there is a built-in filter for checkmate or if you need to filter by the mate text in the PGN.
Looking for just checkmates in a particular opening. Is there a way to do this?