First principles.
I suppose one might start with the question "What is the nature of consciousness?"... Good luck with that. I just make the claim "I think, therefore I am", which, in my view, is a pretty compelling argument, and just leave it that.
Next, start by understanding the universal, logical language of math, so individuals can communicate unequivocally, but that isn't as easy as it sounds. "one plus one equals two"... Really??... PROVE IT. I've seen the proof. It's page after page of set theory and is criticized to this day.
The only practical thing is to assume a generally accepted set of mathematical and logical principles and use those to construct arguments to prove theories, being always mindful of the list of fallacies. If YOU adhere to those principles and you're opposed, fuck 'em. It's not YOUR fault that THEY'RE stupid. If THEY use fallacious argument to "prove" some nonsense you must call them on it. They will generally resist because those using fallacious arguments typically have an agenda, in which case, fuck 'em, It's not YOUR fault that THEY'RE closed-minded.
If you use these first principles to prove an assertion, one can reasonably claim "I know this to be true".
While this is not exactly an astronomy question, it is a science question. And, at least in the last few weeks, we have been getting slightly out of hand with some of our discussions, which keep returning to a difference in what we believe/know. So, I thought that it may be good to start a conversation here, where we can keep it streamlined, organized, and civil. This will also keep us from spamming the front page with our discussion.
As a note, I would like to keep this a religion-free argument, since we are trying to have a productive conversation, and do not want to offend anyone. We also do not need this to discuss this subject. So, how to we know things? How do we separate those things from what we want to believe or want to know? And what what do we need to have sufficient evidence ? I think that these are excellent places to start, establish what we agree on, and go from there.