That is a loaded question. What do you prefer?
The Blocked Center? French and Kings Indian (7...Nc6 vs Classical)
The Mobile Center? Grunfeld and Alekhine
The Static Center? QGD and Closed Ruy Lopez
The Open Center? Petroff and Nimzo lines with early ...d5 and ...c5
The Dynamic Center? Najdorf and Kings Indian (Avoid 7...Nc6 vs Classical, Avoid 6...e5 vs Saemisch)
I've been struggling lately playing on the black pieces. Could anyone suggest an opening that works against e4 and d4? I have no problems with white, so I just need help playing with black.