Are you suggesting that your opponent's response of c5 (I think that's what you meant) to your 1.e4 is terrible?
Sorry I meant d6..yes I think thhat is a horrible response to e4...
1. ...d6 is not a horrible response either. 1. ...g5 and 1. ... b5 are examples of horrible responses. Btw, there are a lot of youtube videos that explain openings in depth. Just make sure the instructor is credible. I like to pick people whom I know are above 2000 rating or have titles.
Look up Nimzo Larsen Attack. It's one of my favorites, as is just about as close as you can get to what you are wanting. Earlier posters are right about KIA, it really can be played against pretty much everything and would probably rank #1 as "I just want to play one opening no matter what they do." Nimzo Larsen would have to be up there though.