Haven't seen this before... strikes me as poor play, as white I'd probably trade bishops and force the black knight to the outside of the board right away, leaving me with total control of the center and black with not much to speak of.
Regardless of what the proper response is; in game explorer, it says white has won 75% of master games where this was played. (A grand total of 16.)
It might work on chess.com because we're not masters, but I'd be a bit surprised if you found it successful.
Has anyone ever given the Guatemala Defense a try? Ive tried researching it and found very little information on it, so if I could get some input that would be great.