The Berlin has absoluetly ruined the Lopez, fun-wise.
If you play it as white, hoping for a6, you go home disappointed because the Berlin is all you see these days. If you played the mainline closed lines as black, you see ten times as many exchanges as you used to because no one wants to face the thing.
Sad days, these.
The Berlin Defence for the Ruy Lopez became popular after Kramnik used it on Kasparov in the Classical World Chess Champion 2000. Fastforward to 2013 and Carlsen uses it against Anand. In both cases, the one who used the Berlin Defence came out on top. This suggests to me that there needs to be a counter to the Berlin Defence or at least a novelty move to throw a wrench into the opening. The reason is that it's a popular and powerful opening that I doubt will go away soon.