Depth 15 is nothing...I use Houdini 3 and on my hardware it reaches depth 25 pretty quickly. Here is the most prominent suggested Houdini improvements for White:
17.Bxd4 (Irontiger's idea) cxd4 18.Nd2 gives White +0.68 at depth 25. Even 17.b4 is better than 17.Nd2.
How much did you pay Critter to play that move? :)
Depth 15 took forever...sounds like I ought to use better hardware.
I doubt that many humans are calculating every variation 25 moves deep.
There is also the so-called "Anti-Portugese" 3.Nf3, with the idea that if Black is taking on d5, White will play d4+c4 as normal, while if Black gambits the pawn White can profit from his ability to play with a pawn on d3 and not d4.
Specifically 3...Bg4 4.Bb5+ Nbd7 5.h3! has been offered by Silman as being good for White.