Yeah, I mean Grischuk played 1.f4 a few days ago in the Sinquefield Cup super tournament against So.
Openings are sort of like... the icing on the cake, the paint on the car. People focus on them too much. What matters is the middlegames you get -- how well you understand them and how well you can play them.
The main lines of classic openings have drawbacks too... namely your opponent is more likely to know those middlegames better. So I don't even, necessarily, make a distinction between "the best possible opening" and "sub-optimal" so long as we're not talking about objective garbage like the latvian or grob.
There are basically two types of openings: those you've studied well, whose middlegames you can handle, and those you can't.
It seems to bit a thorny topic but for openings players seem to fall into 2 camps.
1) Playing the best opening possible trying to maintain and build an advantage.
2) Playing a sub-optimal opening for various reasons (they know it better, easier tactics, confuse opponent etc.).
I am squarely in camp 2, however I would like to hear what others think.
PS. I believe both points of view are valid, and from a super GM level and even World Champion level both have been practiced.