When you realize you have to visualize the entire board in order to make most tactics viable. When your calculating moves based on entire rows, columns and diagonals, or thinking in terms that if you move this or that in the game, then a few moves later, the entire focus of the board moves for whatever position is currently the focus of the board to another wholly different section of the board.
Frequently, there could be simultaneous action on different parts of the board. For example, a rook might be supporting the promotion of a pawn on the far corner of the board, while most of the other few pieces on the board are clustered as far away as possible with your opponent trying to promote a pawn of his own.
Curious as to which factors determine the game is now in it's "endgame" stage?