Well, some opening variations have theory reaching well into the middlegame and even into the endgame. Other variations don't have theory beyond move 5 or 6 yet. It seems that the opening stage is roughly over when the minor pieces have moved at least once and the Rooks are connected.
That's true. Something like the Berlin Defense often plays into theory to a point where it's looking very endgame-ish. I hardly think that still constitutes an opening.
Usually it's where you have to start thinking for yourself.
well said :)