I think the only really independent line after 3c4 is 3...c5xd4 4c4xd5 Nf6 5Qxp Qd5 6Nc3 which might be playable for black, but not too dangerous for white to deal with.
Reverse Queen's Gambit
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I'm interested to know about a reverse Queen's Gambit for Black after 1. Nf3 d5 2. d4 c5. I've begun to play Nf3 as White, usually transposing into the QG, but I'm a little concerned about this line as I find myself rather used to be on the delivering end of the gambit. What would be a good continuation for White? Who has the advantage? Is 3. c4?! a sound move?