The Sicilian is a very interesting opening with many lines, a quote from wikipedia.
The Sicilian is the most popular and best-scoring response to White's first move 1.e4. "Indeed, most statistical surveys suggest that 1.d4 is the most successful first move for White, but only because 1...c5 scores so highly against 1.e4."
Source
http://en.wikipedia.org/wiki/Sicilian_Defence
Here are a few good links to look at in reference:
https://www.youtube.com/watch?v=qzydxPgPKzs
https://www.youtube.com/watch?v=pNILn33kAq8
https://www.youtube.com/watch?v=KfLYXrMoxT0
A list a games played:
http://www.chessgames.com/perl/chesscollection?cid=1004432