Anyone want to theorize here?

So, it's generally accepted the 1.Nf3 is the best opening move for white and 1. ...f6 is the best response. But, obviously in such an unexplored game, there are bound to be those that attempt something different. I've seen 1.e3 played, with the idea to throw off black by playing 2. Qf3 and putting black on the defensive as early as possible. I think after 1.e3 the best response might be 1. ...d5 with the intent of playing 3. ...Bg4 threatening  something like Be2. Anyone want to share in these thoughts? 

doesnt 1. e3, e6 2. Qf3, Qf6 work if you're afraid of losing three pieces and a pawn for a queen?

Yes, but 2. ...Nf6 followed by 3. ...Bg4 seems to get white in immediate danger of losing the game. For example:

Of course, 3. h3 is a placeholder move to demonstrate a point. I'm sure white must have something better there.

If you replace pawn h3 with the knight moving to h3, you can almost force a mate.

The knight cannot be taken (queen captures king after) the king cannot escape, the knight would fork mate, and it's a mate in one if ignored. It can be pretty devastating if played.

It seems if 3. Nh3 black must go 3. ...Bxh3. Afterwards, I guess it's about finding the best moves. Though it seems black will have to be weary about moving the knight on f6. But a reasonable setup should be achievable. If 4. Nc3 or 4. Bb5+, 4. ...c6 should suffice. Then, my consideration would be to long castle. Trying to get Ne4 in, of course. Also, maybe after long castle, a pawn avalanche on the kingside might be effective. Minding the possibilities on the queenside, of course.

ok i checked the engine you dont need to do d5 after e3 you can go e6 and if Qf3 you can block the queen with the f pawn (f5) the threat would (mostly) be diminished

e4, d5, d4, e5, Qe2

After e3 the best is e6,

If you play d5 its happen ( e3, d5, qh5 G6 qe5 Be6 Qxc7

after e3 e6 nf3 the others moves is possible for black one example is qf6 (e3 e6 nf3 qf6)