No way to be able to 100% tell
Consider this...
A very low chance it can even detect the mis clicks, some seem so unusual that it looks like the user played the move with purpose
No way to be able to 100% tell
This. A mis-click could look just like a move or even a blunder. I don't think an algorithm could tell the difference.
Imagine someone plays Hakobyan's repertoire and the system thinks all his moves are mouseslips.
What if Chess.com makes an engine in every game that detects if you or your opponent misclicked? Just a thought...