Specialists in the field other than Pier Luisi clearly do hold out hope that a naturalistic explanation might yet be found, so claiming emphatically that it's a fool's errand might be a little premature?
And to counter the 'well scientists can only pursue naturalistic explanations' argument before it's stated, any field of research that requires funding in a world of strictly limited resources must justify itself by showing the possibility of success, however remote.
But we've been here before! 😉
THE ATHEIST'S MAGICAL, MIRACULOUS FAITH BELIEF IN LIFE FROM NONLIFE
The more I reflect on the origin of life, the more I realize that abiogenesis (life from nonlife) is no less "magical" or "miraculous" than belief that a dead body can come back to life. The same basic degradative processes are at work. This is backed by a tremendous amount of empirical data (like the "Asphalt Paradox" for example). Take for example the "simplest" cell, or an even simpler hypothetical 'minimal life' cell with say 100 genes and 100 proteins, and thousands of copies of each of those 100 proteins for ~1 million molecules total crammed into an approximately ~1 cubic micrometer space (roughly the size of a bacterium or smaller). If we kill that cell by say puncturing the cell membrane, no one expects the cell to come back to life despite the fact that it still has all the necessary parts (and even if we provide enough energy, and all the right conditions, and a controlled environment, and all the time in the world). We can predict empirically time and time again that nothing will happen, and can predict the inevitable decomposition of the cell back into its component parts. It would be "magic" and a miracle for the cell to come back to life.
And yet for some reason many think that if we start with far less than our 100 genes, 100 proteins, and ~1 million total molecules enclosed in a lipid membrane... that if we start with only a small handful of amino acids, and sugars, and fatty acids (a few "nails" and "boards," so to speak, as opposed to an entire "house" that we've knocked out a wall of) that these will spontaneously assemble themselves into a living cell. And this despite the fact that this is simply the working assumption in science. An unproven assumption that has not only not been empirically demonstrated, but that the weight of empirical evidence is against, and that we don't know how it could happen even in theory on paper...
And lest you think this is just the opinion of a non expert, even experts like origin of life researcher Pier Luisi have said as much that we "don't have the slightest idea how life originated from non-life"; and that "we do not have a conceivable theoretical scheme on paper, on how the origin of life may have come about"; and that even the popular "RNA World" hypothesis for the origin of life is "equivalent to invok[ing] a miracle, and then there are other theories based on miracles, which are much more accredited" (See, Dr. Luisi's "The Prebiotic Experiment").
Many agnostics and atheists will often deride, mock, and ridicule theists for their "irrational" beliefs, and invoking "magic" and miracles and silly beliefs like a dead man coming back to life. They have somehow convinced themselves that they hold a "rational," "respectable," "superior" position. And yet I see little difference between the two. Atheism has to appeal to "magic" and miracles, too. Invoking a supernatural agent to originate life is no less magical or miraculous than the atheist's magical, miraculous faith belief that life can spontaneously emerge from non-life.