1.e4,c5 2.b5, now what for black?
hm... you may be on to something. Also he clearly wasn't asking that and was asking the other thing. My bad.

Urk right. I went back and checked one of my games. If White plays his bishop to b5 then a6 is the move for black. I actually did this and white moved to a4. Unfortunately, I was too dumb to press the attack with b5 because then after b3, black plays c4 and traps the bishop. I'm kicking myself now. Thank Urk.

Sorry but 2.b5 is not possible so not at all clear what was ment. Try to use the coordinate and notation well. It will help.

(a) 1. e4 c5 2. b4 ? (a sacrifice the chess engine I play does when it wants to rub my nose in it)
(b) 1. e4 c5 2. Nf3 d6 3. Bb5+ ? ( B51 Sicilian, Canal-Sokolsky (Nimzovich-Rossolimo, Moscow) attack )

Yes true but he said 2.b5 and it could be 2.b4 wing gambit after you can just take 2...cxb4.
It can be 2.Bb5 with is not so strong becuase black can just play 2...a6 an usefull mover to kick the bishop away. Or it can be 3.Bb5 but in this case what are the second moves then? After 1.e4 c5 white can play 2.Nf3 but also 2.Nc3 or even 2.c3 or 2.Ne2. After this moves black can play 2...d6 but also he can play 2.... e6 or 2....g6 or 2....a6 or 2.... Nc6 or even 2....Nf6 so that gives too many variations to answer without knowing what was ment.

Yes true but he said 2.b5 and it could be 2.b4 wing gambit after you can just take 2...cxb4.
It can be 2.Bb5 with is not so strong becuase black can just play 2...a6 an usefull mover to kick the bishop away. Or it can be 3.Bb5 but in this case what are the second moves then? After 1.e4 c5 white can play 2.Nf3 but also 2.Nc3 or even 2.c3 or 2.Ne2. After this moves black can play 2...d6 but also he can play 2.... e6 or 2....g6 or 2....a6 or 2.... Nc6 or even 2....Nf6 so that gives too many variations to answer without knowing what was ment.
Urk right. I went back and checked one of my games. If White plays his bishop to b5 then a6 is the move for black. I actually did this and white moved to a4. Unfortunately, I was too dumb to press the attack with b5 because then after b3, black plays c4 and traps the bishop. I'm kicking myself now. Thank Urk

First of all, this position is not possible (2. b5 is not possible). Secondly, I think you should just ignore it and play something like 2... d6 or 2... d5

People, let me dumb this down to my level. White moves his light square bishop to B5 on his second move. It is indeed possible after e4 on his first move. What aren't we getting here?

You didn't write Bb5, just b5. To me, 2 b4 looked more likely than Bb5 because the first is a recognised opening and the second is meaningless. Bb5 is just met with a6. Immediate equalisation or tiny advantage black.
Thanks for the tips everyone.

Indeed it is [ MeforChessPresident ], in which case as [ urk ] mentioned on #3 reply 2. ... a6
Everybody else got caught up in helpful mode, trying to work out what "2. b5" really meant.

Urk right. I went back and checked one of my games. If White plays his bishop to b5 then a6 is the move for black. I actually did this and white moved to a4. Unfortunately, I was too dumb to press the attack with pawn to b5 because then after white retreats to b3, black plays c4 and traps the bishop. I'm kicking myself now. Thank Urk.
Possibly helpful:
Grandmaster Repertoire 6A - Beating the Anti-Sicilians by Vassilios Kotronias
http://www.qualitychess.co.uk/ebooks/BeatingtheAnti-Sicilians-excerpt.pdf
I've faced this a few times when trying to play the Sicilian. What is Black's best response if White moves their bishop to b5 on the second move? Thanks.