dxe5 would be my vote. It stops black from immediately developing his king's knight to f6, and if black replies ...dxe4, then white can reply Qxd8+ and then black can't castle (granted, not as harmful with queens off the board, but often still an annoyance with all the other pieces still present).
If black tries ...Nc6 instead to regain the pawn on e5, then white can reply exd5 and still be a pawn up (though whether or not he can maintain it long term is another question, but in any case, white can still probably exploit the time it takes for black to regain it).
What do you think is best continuation for white here?