1... e5 is the best reply against e4. It has better drawing chances (which you want as blacks), and gives improvers crucial positions which they need to master.
Best defence against E4

Alekhine defence is by far the strongest. It gives black more chance for win.
agreed

Most Played and Best are not the same. McDonalds's does not have the "best" burgers, yet more are eaten than any other.
Best is anything sound you know deeply.
bad analogy because mcdonalds does have the best burgers

Most Played and Best are not the same. McDonalds's does not have the "best" burgers, yet more are eaten than any other.
Best is anything sound you know deeply.
bad analogy because mcdonalds does have the best burgers
I think I just threw up.

There are so many great defenses, the real question is what is best for you. You have 1...e5 1...c5 1...c6 1...e6 1...Nf6 1...d5 1...d6 1...g6 and even 1...b6 is playable. All of the above are equal (1...b6 is inferior to those as it concedes the center to white for quite awhile but is still playable).
Miles defeated Karpov with 1...a6, but Karpov called it the incorrect opening, you can try out 1...a6 but only for a surprize, white can easily obtain a clear advantage though. Karpov even lost against Spassky despite using the Fischer Defense so even he can be a mortal in the opening sometimes.

Another way of asking this question is: What opening troubles you the most as an e4 player (playing white)? For me, that would either be ...c6 (Caro-Kann) or ...Nf6 (Alekhine).
Most e4 players, like me, want to get their pieces out quickly and strive for open lines leading to a K-side attack. For different reasons, these openings make that straightforward idea difficult.
The C-K is so sound that it is like beating your head against a brick wall. Whereas with Alekhine, you have to be careful about your ambitions to blow black off the board because this defense invites you to overextend your pawns.
I agree that there are lots of good openings against e4, but those two are the most taxing to me personally.

ok you could try the french or e5 they are both good, and although everyone is all for the scillian defence (i never play it) though it may be good i would say it is over rated

Most Played and Best are not the same. McDonalds's does not have the "best" burgers, yet more are eaten than any other.
Best is anything sound you know deeply.
bad analogy because mcdonalds does have the best burgers
What an American.
lol

Making analogies between chess and hamburgers sounds like a questionable enterprise. But, if we're on that topic, In-N-Out clearly has the best burgers.

Most Played and Best are not the same. McDonalds's does not have the "best" burgers, yet more are eaten than any other.
Best is anything sound you know deeply.
bad analogy because mcdonalds does have the best burgers
I think I just threw up.
McDonald's Quarter Pounder Recipe:
1/16 lb 80% lean ground beef
1/8 lb of Fix_a_whole's vomit
1/16 lb of "leanless" beef fat
Two inch by two inch Slice of construction paper the color of American Cheese
Hamburger Bun
Step 1: Churn Beef, Vomit, and Lard to form a 4 ounce lump of paste.
Step 2: Flatten lump of paste and shape it like a circle.
Step 3: Deep fry for 2 minutes
Step 4: Add paper cheese and throw it on a bun. For best taste, drop on the floor two times.
Chili's, Fuddruckers, Hooters, and Five Guys, just to name a few, make a FAR BETTER hamburger than McDonalds. Shoot! Even Wendy's burgers are better than McDonald's!

My vomit is a main ingredient of McDonald's burgers? WHERE ARE MY ROYALTIES!!!!
Each McDonald's Franchise reserves the right to claim ownership of all vomit that lands on property grounds, inside or out. This vomit may or may not contain peanuts!

Now I'm hungry!
that is a picture on an inferior burger. bun is not proper golden brown color. lettuce is placed incorrectly underneath the patty. onions are not chopped. tomato slice and cheese appear adequate but unexceptional. no visible ketchup in picture, indicating a dry burger.
I often use the Sicilian defense variations to win against 1.e4 but I like working with the King's Pawn Games (Italian, Ruy Lopez, Scotch, ETC. with the intentions of playing in a drawish fashion to see if I can squeeze out a win; This gives me a chance to see what kind of player they are in general and what sort of weaknesses they may seem to have, ETC. Players who love 1.e4 and use it almost invariably wiithout much book opening knowledge will many times have difficulties with Caro-Kann openings because they become so used to the similar positions arising from 1.e4 . . .c5 (Sicilian).2.Nf3 and 1.e4 . . .e5 (King's Pawn Game) 2.Nf3 openings that they quickly find themselves in unfamiliar positions when trying 1.e4 . . .c6. 2.Nf3 since the much stronger lines against the Caro-Kann start with 1.e4 . . .c6. 2.d4 and usually then with the response of . . .d7-d5. Remember, The Caro-Kann transposes White away from the White King's Pawn Game opening positional similarities into 1.d4 opening territories (The move 'order' is simply different). In a similar way, A player with the Black pieces that is much more comfortable playing against 1.e4 (and is extremely comfortable with the French defense opening lines, for example) might often respond to 1.d4 with . . .e6 which invites White to use 2.e4 and transposes the opening quickly from a typical 1.d4 opening into what is really a 1.e4 opening by transposition, like 1.d4 . . .e6. 2.e4 (if White cooperates) . . .d5 does for Black to steer into a French defense. The Sicilian, King's Pawn Game, Caro-Kann and French defenses, ETC. are all.great choices for players with the Black pieces;.The next question is then how comfortable are they with using these and how many times have they won or lost trying to use them with the black pieces.