Yeah, I have no idea if there is a good defense or not but I seriously doubt it. White scores ridiculously well after 5...Nxd5. Pinski gives the move a question mark (apparently for good reason).
Defending the Lolli Attack from the Two Knights Defense

This is not correctly played. After 6.d4 the best move is 6...Be6 7.O-O and white just has a slight edge.

Most people don't play 5 Nxd5 and instead opt for 5 Na5 giving up the pawn in exchange for some iniative.

6. d4 Nxd4! 7. c3 b5! is probably the critical continuation where white might be slightly better

This is not correctly played. After 6.d4 the best move is 6...Be6 7.O-O and white just has a slight edge.
Currently, I have an opening with almost 100% win rate OTB and online (mostly OTB). It is the Lolli Attack against the Two Knights Defense which goes like this: 1. e4 e5 2. Nf3 Nc6 3. Bc4 Nf6 4. Ng5 d5 5. exd5 Nxd5?! 6. d4! exd4 .
However, I'm quite interested with the fact that many people prefer the Fried Liver (6. Nxf7!?) than Lolli. I wonder if someone can find a good defense against the Lolli? If there is none, then Fried Liver will not be a good option anymore.