I don't think you can really say that elite players can't "get out of the box" when they themselves are making "the box"
You can, because the implied point is that they can't break out of the habits (or trends) that they created themselves. Because they play a select amount of openings, rightly so, for that creates the best winning chances for them, they 'create' the box and then can't get out of it because it offers them the considerable weight of reliable theory.
That isn't to say that it doesn't make me sad (I'd like to see more Caro-Kanns, for example!), as I was a little depressed that not a single game of 1.e4 was played in the recent WC, but it's true that they stick to a certain standard set.
because it's silly to consider them just one opening. e4-e5; Nf3 is not just one opening. of course there is no objective criteria out there but few theorists would consider the QG just "one opening".