First historical appearance of openings in 2 plies

I'm planning to make an extensive list ordered lexicographically by PSCC (pawn structure classification codes). 

1. 1C 1. c3 Nc6 Saragossa: QN, Lucena-Quintana (1-0), 1515, http://www.chessgames.com/perl/chessgame?gid=1466107
2. 2Ec 1. e4 c5 Sicilian defense, Greco-NN (1-0), 1620, http://www.chessgames.com/perl/chessgame?gid=1271592
3. 2Ed 1. e4 d5 Scandinavian defense, Castellvi-Vinyoles (1-0), 1475, http://www.chessgames.com/perl/chessgame?gid=1259987
4. 2Ee 1. e4 e5 KPG, Damiano-NN (1-0), 1497, http://www.chessgames.com/perl/chessgame?gid=1336243
5. 2E1b 1. e4 b6 Owen defense, Greco-NN (1-0), 1619, http://www.chessgames.com/perl/chessgame?gid=1243022
6. 2E1e 1. e4 e6 French defense, NN-Greco (0-1), 1620, http://www.chessgames.com/perl/chessgame?gid=1271145
7. 2e1E 1. e3 e5 Reversed French, NN-Lucena (0-1), 1497, http://www.chessgames.com/perl/chessgame?gid=1544951

(to be continued)

The most original opening Saragossa: Queen's Knight appeared in Lucena-Quintana game 500 years ago :

The Sicilian defense: Wing gambit was played already by Greco in 1620. 

Greco also played and studied the French defense.