FurryKittens: My last comment was posted before I read your last comment. Good point that if I'm trying to avoid lots of theory, Game Explorer probably isn't the greatest way to analyze an opening's potential.
For what it's worth, the look and feel of those first 6 moves are enticing. Also, you've expressed more fervent advocacy of it than anyone else has of a different opening, which totally counts. Oh, and extra points for sweet name & avatar.
DrSpudnik: fair point, although "statistically reliable" is a bit ambiguous. I'm fairly confident that such a large disparity in win/loss ratio between a sample size of 354 and a sample size of thousands (Ruy, Italian etc.) would be a statistically significant difference. Honestly that's a guess, but I'd bet on it.
Regardless, though, I can't see past giving black a free developing move. I hate to be a closed-minded negative nancy, but retreating to e3 as the best move after allowing a solid developing move would just feel horrible.
Furthermore, with rare openings, I suspect that if anything, white should be slightly more likely to win than if the opening become more popular, as white has presumably studied the opening more thoroughly than black (on average), so black would be operating under a time disadvantage.
In the case of the Ponziani I'd be open to the argument that there just aren't enough games, because the very close win/loss ratio is all I'm going on, but in the center game after Nc3, black has won more AND there's an identifiable weakness in the opening: giving up a tempo. [I realize that I'm looking at this very superficially and simplifying perhaps to an erroneous degree]