I don't think the Sicilian is an opening you will be 'sliced and diced' by at the sub-2000 level ;)....
In addition to 1...e5 there are a number of other possible replies: 1...c5 is the most popular move in tournament play (the Sicilian Defense). Here the main line runs 2.Nf3 followed by 3.d4 against most Black moves (2...a6 in particular is not met by 3.d4 but instead by either 3.c4 or 3.c3, for reasons I would not like to go into in any kind of introduction to playing 1.e4) and this is called the Open sicilian. Black will take on d4 most of the time and White will recapture with the Knight. This creates an imbalance: Black has a queenside minority (the minority attack is an overarching theme in many Sicilian defenses) and an extra central pawn, White develops the pieces more easily and can attack more easily, generally speaking. These lines are lots of fun for both sides! Other possibilities exist but this is my recommendation.....
1...e6 is the third most common move (after 1...c5 and 1...e5) and this is called the French defense. As a general rule, if Black lets you play 2.d4 without either controlling that square with a pawn or attacking your e4 pawn (or hanging a pawn with 1...b5) it is advisable to play it on move two. So 1.e4 e6 2.d4 d5 (attacking the e4 Pawn) and now the main move is 3.Nc3 defending the pawn......
The best way to learn is to play games! See what you like and don't like. Play through some famous games (I could recommend a few as could other players) to learn the basic ideas, attacks and defenses, etc. Good luck!
After playing chess for 35+ years it has been my experience and that of grandmasters, that the Sicilian Defense, (particularly the Najdorf variation), is the opening black wants to use when playing for a win against 1.e4 and the Sicilian Defense has the highest winning percentages against 1.e4. Once understood, it is an excellent opening for black to play. The Sicilian Najdorf, 1.e4, c5 2.Nf3, d6 3. d4, cxd 4.Nxd, Nf6 5. Nc3, a6 is known far and wide as an extremely potent defense that can turn into a vicious attack very quickly. In some lines, it isn't even necessary for black to castle, which can lead to a massive, overwhelming and decisive kingside attack against white. One of the all time best Sicilian Najdorf players in the history of the game is Bobby Fischer, an expert on this opening. Here is a great video of one of his fantastic games using the Sicialin Najdorf --> http://www.youtube.com/watch?v=1tw_wsPmtTg
The tables can be turned on the French Defense with the Reti Gambit and it has very high winning percentages vs the French Defense. 1.e4, e6 2. b3! Here is a fantastic video on this potent opening that used properly, can make your French Defense playing opponent quite uncomfortable. Enjoy.
-> http://www.youtube.com/watch?v=w53jqnNrOo0
If we just play games, making the same mistakes over and over again, becoming frustrated, it might have a very negative outcome with a players game. I personally feel the best way to improve one's play is by analyzing grandmaster games, which teaches the player the expert moves a grandmaster makes and the reasons behind them. From chess legend Anatoly Karpov's excellent book, How to Play the English Opening, http://www.barnesandnoble.com/w/how-to-play-the-english-opening-anatoly-karpov/1008460046?ean=9780713490657&itm=1&usri=how%2bto%2bplay%2bthe%2benglish%2bopening
"Karpov believes the best way to learn an opening is to play through the well-annotated grandmaster games, and then you will assimilate the recurring ideas, plans and tactics naturally, almost effortlessly - in much the same way as you would best learn a foreign language by talking to native speakers".
One of the very best books I can recommend for any chess player, (especially today with so many player's making the mistake of trying to mimic the play of a chess computer), is -> "Winning With Chess Psychology", by Pal Benko, International Grandmaster. Benko was one of the few grandmasters who could give Bobby Fischer a tough time and defeated Fischer more than once. In other words, he knows his stuff.
This great book is currently out of print but you can still obtain a good used copy from Barnes and Noble for only $2.69 --> http://www.barnesandnoble.com/s/winning-with-chess-psychology

The Fegatello variation of the Italian game (known also as the Fried Liver) comes about only after a very risky move by Black.
For players new to 1.e4, it is often recommended to play the Italian game.
1.e4 e5 2.Nf3 Nc6 3.Bc4. This is a very old opening with a long tradition that has been played by many top players throughout the centuries.
Here, the most popular move, 3...Nf6, can be met by 4.Ng5. This violates opening principles by moving the same piece twice in the opening, and by attacking before developing the army. However, it has some sting to it as there are two minor pieces attacking Black's weak point at f7, and it is only defended by the King.
The only three reasonable moves here for Black are the intuitive 4...d5 (blocking the Bishop), 4...Bc5!? (the Traxler counterattack), and 4...Nxe4!? (a very counterintuitive move you may never see).
Every other move is bad. 4....h6 5.Nxf7 is the classic example, forking rook and queen.
4...Qe7 is best met by 5.Bxf7+. A common beginner mistake here is 5.Nxf7 Rg8 6.Nd6+? (better is 6.Ng5 with a White advantage) 6...cxd6 (or Qxd6) 7.Bxg8 Nxg8 with advantage to Black. White has given up his two developed pieces for a rook and a pawn, and Black can still castle queenside so he is perfectly safe.
4...Rg8 5.Bxf7+ is another double attack.
So after the most common move, 4...d5, White takes the pawn 5.exd5 and here Black has a number of reasonable moves. Most common is 5...Na5, sacrificing the pawn and attacking the bishop. This is Black's best try.
The risky 5...Nxd5!? is played mostly by beginners. At beginner level it is instructive to play through the Fried Liver Attack, which begins 6.Nxf7 Kxf7 7.Qf3+. Here White is much better if Black does not defend the knight with the insane-looking 7...Ke6 because White will simply capture on d5 with the Bishop threatening various checkmates on f7/g5. After 7...Ke6 8.Nc3 White is attacking the pinned piece again. The game from here gets very complicated! So work on tactics and increase your winning chances.
6.d4 is probably objectively a stronger move than 6.Nxf7. The idea is to sacrifice on f7 only after developing more.