Opening theory is based off of responses to moves, that is why there are so many variations.
If your opponent does something "unusual" you are no longer in that line of theory or if it is early enough it could just be a transposition that will result in the same position eventually anyway.
Best thing to do is to look for a logical move that grabs space, develops pieces, or makes threats and after the game look up common responses to that move. If you don't find that move in the database then think about what is weak about it that causes no one to play it.
Would you continue on theory and hope there move doesnt matter. Or would you look at it for a while and try to come with a completely different plan?? Any advice?