These are fairly unusual positions, haha. It took me a while to figure it out, but do you mean 2... e6 and 2... c6?
edit: I'm not at the level to answer your question. But it seems you're asking why Slav defense requires different follow up than QGD? Not sure that's easy to answer, but I'm sure some educational content is available on YouTube.
After 1. d4 d5 2. c4 I noticed in the games database that:
Why is that?
(In fact, I -- a newbie to 1 d4 -- would have thought the opposite, because 2...e6 3. Nc3 walks into a Nimzo, 3...Bb4, which some prefer not to play against)