It's interesting that we associate the Ruy Exchange variation with Lasker although he rarely used it. He used it in several important games spread throughout his career.
Ruy Defense

I associate lasker as black mainly with the steinitz variation, but i haven't really checked so i might be wrong.

Reb, I believe Korchnoi was a avid user of the Open for a while. At least it seemed he was one of the last ones to use it regularly.
Wow. I am quite surprised by Lasker. But it's true that he played tons of different stuff.
I also only looked at free online databases. Botvinnik apparently played it at least 5 times, mainly in the Absolute URSS championship, against very strong opposition.