Which Defense is the Best Against White's 1.) e4?

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What is Black's best defensive opening for White's King Pawn Opening?  Are these games more sharp tactically?  UndecidedMany people are reading this blog but no one seems to want to comment on it!  WinkCome on guys(and girls, too) what do you think?  Do not be afraid of exposing your own favorite opening here!  Let's have a discussion on the topic!Smile   *Hint: Read my blog post entry entitiled: "The Best Defense for White's King Pawn Opening.".  -  ChessPaladin2009Cool

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What is Black's best defense?  Sicilian or something else?  Please let me know!  Thanks! Smile Below is a line in the Najdorf Variation on the Sicilian Defense:

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4. Qb5 check.