Obviously, the title should have read "non-Sicilian", not "non-Silician". 
The most "non-Silician" 2. move after 1. e4 c5
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What about 2. c3 ?
That might be. I've tried with 2. Ne7, but that seems to still lead to "Sicilian-like" positions, just a little "delayed".
Hope this helps.
The move 3. Bb5 is the Rossilimo and us fairly popular. But as the OP was looking for alternative to 2. Nf3, i would recommend 2. c4 or 2. B3. C4 is obviously the more practiced of the two while b3 is probably not the best but will most likely take black into strangeland and out of any lines he might be prepared for.
Paul..., I would prefer a move instead of 2. Nf3. But this is interesting, anyhow. Thanks! Any suggestions for a substitute for 2. Nf3?
Thanks, Peedee! You expressed it better than me. Taken Black into strangeland as soon as possible is exactly what I would like to do. With a playable line, of course.
If you're looking to deviate at move 2, I'd recommend...
2.Nc3, followed by 3.g3 (the "Closed Siclilian") if you're looking for a closed, manouvering type game. In general, focus is on a slow, steady buildup on the kingside.
or
2.c3, typically followed by 3.d4 (the "Alapin Sicilian") if you're looking for a more open game with lots of piece play.
The first will probably appeal if you play a lot of openings like the Ruy Lopez, the Advance Caro, or the Austrian against the Pirc, for example. Or stuff like the KID as black.
The second more if you play the KG or Italian (non-d3 lines), or the Panov against the Caro. Or the Tarrasch as black, e.g. Lots of isolanis in the c3 lines.
Oct 14, 2011
0
#10
after 1. e4 c5 I sugest to leave most theory with the move in the diagram
jetfighter13 wrote:
after 1. e4 c5 I sugest to leave most theory with the move in the diagram
That's an especially good line to play against an opponent who has a phobia against playing Bg4.
Thanks, paul.... However, I have no interest in playing computers.
cigoL wrote:
Paul..., I would prefer a move instead of 2. Nf3. But this is interesting, anyhow. Thanks! Any suggestions for a substitute for 2. Nf3?
I love playing 2. Nc3 and 3. f4, though mostly in live chess. I used to play 1.d4 instead of 1.e4 to avoid the sicilian, but now I sometimes hope to see the reply 1...c5
I barely know anything about sicilians, let alone silicians... 
If you REALLY want to get out of theory though:
(BTW not sure if its solid it looks ok to me)
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I used to play the Kopec System against the Sicilian, and I opened with 1. e4 c5 2. Bd3
That was a long time ago, and I'm not sure if the move order is sound. It is supposed to be 2. Nf3 d6 3. Bd3
If you are looking for an unusual anti-Sicilian, check out the Kopec.
alapin
Thanks everyone! I've listened to you all, and have now decided what my reply to the Sicilian Defense will be. Thanks! 
Oct 15, 2011
0
#20
paul211 wrote:
The most unusual move has been 1.e4 c5 2.Na3, why you ask, simply to deviate from theory and memorization of variations.
Etc. ETC. ETC..
I played this opening 3 times and my oponents where completely lost, I won all 3 games.
Impossible to follow all the moves in your head just by reading them.
Denver
After 1. e4 c5 the typical White move is 2. Nf3.
After 2. Nf3 Black has quite a bit of possible replies, all leading to some Sicilian kind of position down the line.
Now, after 1. e4 c5, what White reply is most likely not to lead to a Sicilian like position 10 or so moves into the game?