I quite like playing the Jaenisch (3 ... f5) against the Ruy Lopez. You have to assume your opponent will play the Ruy Lopez though. 3... f5 isn't that great against Giuoco Piano (Italian) as the bishop on c4 makes it hard to castle, and white gets good play with 4. d4. I still played it in my current daily chess game though (when my opponent played 4. d3 which is also a reasonable move).
Yes, 3...f5 is pretty much unsound against 3 Bc4 – and also against 3 Nc3.
You play e5 after having a few bad Sicilians as black.