I think the best way is to do some research on the different types and pick one that suits your playing style. I've read that generally, 1. e4 leads to open, tactical games, while 1. d4 leads to more closed, positional games. Of course, nothing is set in stone and there are no hard and fast rules, but using this as a guide caused me to switch to opening games as white with e4 (when I first started, I used d4 just because). This will guide games into positions with which you are more comfortable.
For black, I'd say pick one response to e4 and one to d4, again, suiting your style.
It will take time to discover your style, and therefore which opening you like. I've been playing for about two years and I'm still figuring it out.
It can be frustrating learning an opening only to have your opponent take you out of it early on, but hey, he has his own playing style too.
I'm a relative beginner and just starting to explore the Opening phase. So far, I've been using Fritz 12 to try and choose an Opening - or a selection of Openings - to focus on.
I am aware of different named Openings (e.g. Barcza Opening; Queen's Gambit Declined; etc.), but just looking at them - either on Wikipedia, or ChessGames.com, etc. - didn't give me much of an inkling as why one Opening would be better than another.
I've done some analysis with Fritz 12, but was interested to see what "human" chess players did.
So, what's come to be your favorite Openings (either as White, Black, or both) and how did you come to focus on them?