Here it's possible to get a feel of 3D chess. https://www.chessvariants.com/play/jocly/raumschach
By the way the knight is quite strong as it can reach 24 squares from the center of the board.
Is it possible to place 8 queen inside a 8x8x8 cube without any threatens each other.
True, even on the first move both sides have..well let's see..
2 possible pawn moves for each of the 64 pawns, = 128 pawn moves. Next we have the 20 knights, each with 8 possible upwards moves jumping over the pawn, so 160 possible knight moves.
128+160= 288 possible first moves for each side, so
288 X 288 =82,944 positions after the first move, that's quite a thick opening book lol