Looks like the pros choose e4 by a convincing margin. This is from the Explorer master games...
-
103,223
40%32%28% -
21,246
40%34%26% -
37%34%29%
-
40%33%27%
-
32%30%38%
-
38%23%39%
-
31%51%
-
41%32%26%
-
24%32%44%
-
30%70%
-
80%20%
-
25%25%50%
-
67%33%
d4 e6 best reply for white