"I lose because my opponent(bots) played Horwitz defense"
It is certainly not "because". You lose because of your mistakes, not because of the opening.
How to avoid Horwitz defense?
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Playing d4 means you are playing as white. In your profile, you are losing with e4 though.
Post a game where you lost with you as white and playing d4 and black playing e6. Then, you can work to win with d4 and black playing e6.
Anytime you need help, post a game with an example of what you are asking about.