It's not possible to give odds at this time, but the idea has been brought up before. I really hope the chess.com staff will implement this in the future.
giving an opponent odds
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Sep 2, 2010
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#3
You could move the pieces around to achieve any starting position (a Takeback game would be a particularly handy way of doing it). Such a game would naturally be unrated.
You may be interested in this list of balancing mechanisms - and another set for fairer team matches.
On this site, is their a way to challenge someone to a game in which you start down a piece? I know you can choose any of the opening positions in chess.com's opening book to start from, but is there a way to simply start down a piece? If not I think this should be an option.