How to fight with premovers?

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GreedyPawnGrabber

 When you smell a premover(a patzer playing on time) do you try to guess what's his next premove and play a possible bad move which can give you an advantage?

cabbagecrates

I have been black a few times in e4 d5 nf3 d5xe4.  That doesn't look a good opening to me, and so I assume it is a pre-move by white at move 2.  But it might be ok.  As I'm a patzer I'm not sure.

I like the sound of your plan though.  Does it work?