You sure you mean "!N" and not just "N"? I think that "!" and "N" are two different symbols. "!" or exclam just means a very good move. "N" is just novelty.
I haven't bought an Informant in quite a while but I thought you could have good novelties and dubious novelties.
http://www.chessinformant.org/system-of-signs/
Ok, I have a good idea what a !N Novelty is, since I own several Informant books, and I think they invented the term. However, I have never seen an exact verbal definition. My own understanding is the following: 1) Has to be played by a Grandmaster in an official tournament game. 2) Has to be a new move in a specific, known, theoretical position. Even if the move is a `no brainer`, for example, I have seen annotaters give Nf3, a !N Novelty designation, even in normal looking positions if they didn't find the move in their data base. So anyway, let's hear what you think defines a !N Novelty.