Sorry, but that doesn't make sense.
what is the best defense against 1. c4
The 'Best' defense for you; Is that 'line' {of the '6'? available}; Which you feel most comfortable 'playing.' -- It's somewhat like asking; "What's the 'Best' item, to 'order'.. at a '4-or5 Star' restaurant; That serve numerous, tasty 'dishes'!? 0:

The three major replies to 1.c4 are e5, c5 and Nf6. Then you could also play f5, e6, c6 or g6. A lot of these (aside from e5 and c5) have tons of transpositional possibilities, so you have a bit to work on.
my opponent played this after i open queens pawn game. After that my whole game just fell apart.