Even if you could manage to get your opponent's king cornered exclusively with pre-moves, I suspect that there would always be a possibility of stalemate.
Winning on premoves


If you cannot know the next move for the lone K, only the most trivial position of K+Q v K is winnable on premoves alone (i.e., no knowledge of the lone K's moves). Mate in 1, with either side to move would work without knowledge of the opponent's moves, would work. If you have to see the movement of the lone K to decide on the Q or K move to make, then you cannot use premove and be sure of anything. Yes, you could luck in to longer mate, I'm sure. But you could just as easily lose your Q or make an illegal K move. Of course, I might have misunderstood your question to begin with.

That's no problem if you can enter many lines, I'm not a paying member so I can just premvove one line.
Stalemate is no real danger.

ok, I did read a bit fast then, premove in live chess is a bit more dangerous!
So the answer is:
No way you can premove to mate in live chess, somewere your opponent does a move that don't fit in your plans.
Premove in livechess is so you can play a move without using time at all, premove in "postal" is so you can let the game go on alone while you do something better

So if I can't premove mate with a queen, what is the smallest amount of material where it is possible? I can see two rooks being easy.
I think we all know how to mate with 2 rooks, how does this prove annything?
Black could have gone anny other way with his king many times, if it happens once you have to do a move live, then it's not a premove.

It could be done with premoves. I challenge everyone here to a premove game.
You need to capture one of my rooks to win, I need to checkmate your king in order to win.

Is there a way to win a K and Q vs. K endgame completely on premoves? assuming your opponent gives you enouph time to enter the premove.