Definitely. Being used to chess.com I didn't ralise lichess had takebacks when I played there until someone requested one. I still won the game, but my immediate thought was "what is the point in us playing this game if you are just going to ask for a takeback when you make a bad move". Needless to say after that game I disabled takebacks.
I don't mind takebacks, but only in obvious mouse slips. I have granted two so far, never had any more requests though :)
i've had mouse slips before as well and now i almost never click and drag the pieces. i click piece and click square i want to move it to. much safer ;)
If I could choose to only allow requests for mouse slips then I would likely accept them, but I don't want all the other spurious requests so unfortunately for my opponents who make mouse slips they just have to accept them as part of online chess.