You can cancel premoves with a right click. Since multiple moves can be stacked, clicking another piece just allows you to add another premove.
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I'm using LiveChess from a PC and Chrome browser. Here on chess.com, premove is allowed and you can select a piece for premove before the opponent moves. And to change selection of pieces, you need TWO clicks; first to de-select the premove piece, and second to select another piece. This gives shameless flaggers undue advantage. They can always make the premove without any positional considerations -- with totally lost positions, they never need to change selections.
Other major chess sites do it in ONE click; clicking on a new piece automatically de-select the premove piece. Chess.com should adopt this one-click way to re-select, or at least provide it as an option in 'Settings'. This will have a good side-effect of discouraging flaggers and attracting more good players from other sites.