The Sicilian has been extensively studied, and there are many variations. A popular variation is the "Dragon" variation, which starts as:
1. e4 c5 2. Nf3 d6 3. d4 cxd4 4. Nxd4 Nf6 5. Nc3 g6
In this variation, Black finachettos a bishop on the h8-a1 diagonal. This is called the "Dragon" variation because Black's pawn structure is supposed to look like a dragon.
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Another variation that's quite popular is the "Najdorf" variation. It starts just like the Dragon, and diverges on Black's move 5:
1. e4 c5 2. Nf3 d6 3. d4 cxd4 4. Nxd4 Nf6 5. Nc3 a6
According to Grandmaster Daniel King White often responds with "Be2", permitting Black to attack the center with "e5!".
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