Patzer Opening: Black responds d6
The second main response to the Patzer is d6.
Here is a possible standard line.
Note that White need not play 5.Ne2 before Qb3 as Black does not have Nd4 available, yet.
Here is an example of the problems if not 5.Qb3 and as well not Ne2 nor c3.
See here for the complete game http://www.chess.com/echess/game.html?id=202511
Best play for White - not 4.Qf3?
With the Queen on f3 and White preferring to deploy the knight to f3, perhaps it is better if White plays 4.Qe2 or 4.Qd1.
See here for the complete game http://www.chess.com/echess/game.html?id=5504541
Here is a possibly more balanced variation.