But at least I doubt the Ruy Lopez is theoretically the best. It might be practically.
One good line of black against the Ruy Lopes is:
1.e4 e5 2.Nf3 Nc6 3.Bb5 Ne7! And black has actually in most lines the better statistics.
The reason is simple: The Ruy Lopez lives on attacking the Nf6 and using the f5 square. So Nf6 is actually a weak move to do, and Nge7 is more logical: It supports f7-f5, and deprives white of the attacking target on f6.
I am not saying that 3...Ne7 is a refutation of the Ruy Lopez, but I could imagine, that one day the world opens their eyes and sees find this move. Some players seem to have discovered it already, and 3...Ne7 advanced to the 3rd most played move here.
The Berlin against the Ruy Lopez is still giving white a target on f6, but seems to take a lot of fun for Ruy Lopez players, too. If you dont like 3...Ne7 (but why shouldnt you?), then the berlin is good enough to make the Ruy Lopez look a bit blunt.
For the Queens gambit: the attacking chances of black in the orthodox QGD (with e6) seem to give black practically good chances at club level. Only at GM level, white can parry these attacks sufficiently and keep a tiny edge. I believe, that the Catalan is stronger than the queens gambit. Theoretically and especially practically, because in the Catalan, black wont have attacking chances on the kingswing, but the minority attack is still an option in some lines for white. The bishop on g2 is just more useful for white in terms of defense as well as putting pressure on the black center and queenswing.
The answer to that is a bit strange. No, it is rather "unusual", not strange.
There are 2 best moves after 1.Nf3 d5, dependend on what you assume means "best".
Best in practical terms is certainly 1.Nf3 d5 2.c4, and it is what I play mostly.
However, best in theoretical terms is 1.Nf3 d5 2.d4
What is the difference?
After 1.Nf3 d5 2.c4 white scores better (practical aspect), but the theoretical best answer to this line is for black 2...d4. If white continues like I do: 3.e3 then black has the relative good answer 3...Nc6.
It is practically not so often played though.
In contrast: after 1.Nf3 d5 2.d4 white still scores practically well, but not as well as with 2.c4. However, there is no (seldom) good answer for black here. So 2.d4 is theoretically "best".