If you mean scholars mate, any opening is very good against it. If you are just falling over yourself in fear of it, then use the caro-kann.
best opennings

To add clarity, are you asking about the Trompowsky Attack (1.d4 Nf6 2.Bg5)?
i.e. http://finaltheoryofchess.game-server.cc/mediawiki/index.php/1.d4_Nf6_2.Bg5
Which openning is the best defese against the queen- bishop attack?